Listar por autor "Gato Cañas, María"
Mostrando ítems 1-6 de 6
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Early detection of hyperprogressive disease in non-small cell lung cancer by monitoring of systemic T cell dynamics
Arasanz Esteban, Hugo; Zuazo Ibarra, Miren ; Bocanegra Gondán, Ana Isabel; Gato Cañas, María; Martínez Aguillo, Maite; Morilla Ruiz, Idoia (MDPI, 2020) Artículo / ArtikuluaHyperprogressive disease (HPD) is an adverse outcome of immunotherapy consisting of an acceleration of tumor growth associated with prompt clinical deterioration. The definitions based on radiological evaluation present ... -
Molecular mechanisms of programmed cell death-1 dependent T cell suppression: relevance for immunotherapy
Zuazo Ibarra, Miren ; Gato Cañas, María; Llorente, Noelia; Ibáñez-Vea, María ; Arasanz Esteban, Hugo; Kochan, Grazyna; Escors Murugarren, David (AME Publishing, 2017) Artículo / ArtikuluaProgrammed cell death-1 (PD1) has become a significant target for cancer immunotherapy. PD1 and its receptor programmed cell death 1 ligand 1 (PDL1) are key regulatory physiological immune checkpoints that maintain ... -
PD1 signal transduction pathways in T cells
Arasanz Esteban, Hugo; Gato Cañas, María; Zuazo Ibarra, Miren ; Ibáñez-Vea, María ; Breckpot, Karine; Kochan, Grazyna; Escors Murugarren, David (Impact Journals, 2017) Artículo / ArtikuluaThe use of immune checkpoint inhibitors for the treatment of cancer is revolutionizing oncology. Amongst these therapeutic agents, antibodies that block PD-L1/PD1 interactions between cancer cells and T cells are demonstrating ... -
PDL1 signals through conserved sequence motifs to overcome interferon-mediated cytotoxicity
Gato Cañas, María; Zuazo Ibarra, Miren ; Arasanz Esteban, Hugo; Ibáñez-Vea, María ; Lorenzo, Laura; Fernandez-Hinojal, Gonzalo; Vera García, Ruth; Smerdou, Cristian; Martisova, Eva; Arozarena Martinicorena, Imanol; Wellbrock, Claudia; Llopiz, Diana; Ruiz, Marta; Sarobe, Pablo; Breckpot, Karine; Kochan, Grazyna; Escors Murugarren, David (Elsevier, 2017) Artículo / ArtikuluaPDL1 blockade produces remarkable clinical responses, thought to occur by T cell reactivation through prevention of PDL1-PD1 T cell inhibitory interactions. Here, we find that PDL1 cell-intrinsic signaling protects cancer ... -
A proteomic atlas of lineage and cancer-polarized expression modules in myeloid cells modeling immunosuppressive tumor-infiltrating subsets
Blanco, Ester; Ibáñez-Vea, María ; Hernández, Carlos; Drici, Lylia; Martínez de Morentin Iribarren, Xabier; Gato Cañas, María; Ausín, Karina; Bocanegra Gondán, Ana Isabel; Zuazo Ibarra, Miren ; Chocarro, Luisa ; Arasanz Esteban, Hugo; Fernández Hinojal, Gonzalo; Fernández Irigoyen, Joaquín ; Smerdou, Cristian; Garnica, Maider; Echaide Górriz, Míriam; Fernández Rubio, Leticia; Morente Sancho, Pilar; Ramos-Castellanos, Pablo; Llopiz, Diana; Santamaría, Enrique; Larsen, Martin R.; Escors Murugarren, David; Kochan, Grazyna (MDPI, 2021) Artículo / ArtikuluaMonocytic and granulocytic myeloid-derived suppressor cells together with tumor-infiltrating macrophages constitute the main tumor-infiltrating immunosuppressive myeloid populations. Due to the phenotypic resemblance to ... -
Study of two barriers in melanoma immunotherapy; myeloid derived suppressor cells and PD-L1/P-D1 inhibitory interaction
Los tumores escapan eficazmente del ataque inmunitario al inhibir las actividades antitumorales de las células T. Esto se logra mediante al menos dos mecanismos principales. En primer lugar por el establecimiento de ...